| Ohio at Akron | Tue Nov 3, 7:00 PM | | | | |
| Buffalo at Miami (OH) | Tue Nov 3, 7:00 PM | | | | |
| Ball State at Massachusetts | Wed Nov 4, 12:00 AM | | | | |
| Central Michigan vs Eastern Michigan | Wed Nov 4, 12:00 AM | | | | |
| Toledo at Sacramento State | Wed Nov 4, 12:00 AM | | | | |
| UTSA at Florida Atlantic | Thu Nov 5, 8:00 PM | | | | |
| James Madison at Southern Miss | Thu Nov 5, 8:00 PM | | | | |
| Virginia Tech at No. 22 SMU | Fri Nov 6, 7:00 PM | | | | |
| South Florida at East Carolina | Fri Nov 6, 7:30 PM | | | | |
| Nebraska at Illinois | Fri Nov 6, 8:00 PM | | | | |
| New Mexico at Nevada | Fri Nov 6, 9:00 PM | | | | |
| TCU at Arizona | Fri Nov 6, 10:15 PM | | | | |
| Arkansas at Auburn | Sat Nov 7, 12:00 AM | | | | |
| Oklahoma at No. 21 Florida | Sat Nov 7, 12:00 AM | | | | |
| No. 8 Alabama at No. 10 LSU | Sat Nov 7, 12:00 AM | LSU -3.5 | 54.5 | | |
| No. 2 Georgia at No. 4 Ole Miss | Sat Nov 7, 12:00 AM | Ole Miss +4.5 | 55.5 | | |
| Vanderbilt at No. 24 Mississippi State | Sat Nov 7, 12:00 AM | | | | |
| No. 1 Texas at No. 19 Missouri | Sat Nov 7, 12:00 AM | | | | |
| No. 23 Texas A&M at South Carolina | Sat Nov 7, 12:00 AM | | | | |
| Kentucky at No. 14 Tennessee | Sat Nov 7, 12:00 AM | | | | |
| No. 9 BYU at No. 15 Utah | Sat Nov 7, 12:00 AM | Utah -3 | 51.5 | | |
| UCF at Kansas | Sat Nov 7, 12:00 AM | | | | |
| Cincinnati at No. 25 Houston | Sat Nov 7, 12:00 AM | | | | |
| Colorado at Arizona State | Sat Nov 7, 12:00 AM | | | | |
| Iowa State at Baylor | Sat Nov 7, 12:00 AM | | | | |
| Oklahoma State at Kansas State | Sat Nov 7, 12:00 AM | | | | |
| West Virginia at No. 11 Texas Tech | Sat Nov 7, 12:00 AM | | | | |
| Clemson at Syracuse | Sat Nov 7, 12:00 AM | | | | |
| Duke at NC State | Sat Nov 7, 12:00 AM | | | | |
| No. 16 Louisville at Georgia Tech | Sat Nov 7, 12:00 AM | | | | |
| Florida State at Boston College | Sat Nov 7, 12:00 AM | | | | |
| Merrimack at Wake Forest | Sat Nov 7, 12:00 AM | | | | |
| Michigan State at No. 18 Michigan | Sat Nov 7, 12:00 AM | Michigan -16.5 | 50.5 | | |
| UCLA at Minnesota | Sat Nov 7, 12:00 AM | | | | |
| No. 17 Iowa at Northwestern | Sat Nov 7, 12:00 AM | | | | |
| No. 20 Oregon at No. 7 Ohio State | Sat Nov 7, 12:00 AM | Ohio State -6 | 52.5 | | |
| Maryland at Purdue | Sat Nov 7, 12:00 AM | | | | |
| No. 13 Penn State at Washington | Sat Nov 7, 12:00 AM | | | | |
| Rutgers at Wisconsin | Sat Nov 7, 12:00 AM | | | | |
| Charlotte at UAB | Sat Nov 7, 12:00 AM | | | | |
| Rice at North Texas | Sat Nov 7, 12:00 AM | | | | |
| Tulsa at Tulane | Sat Nov 7, 12:00 AM | | | | |
| Hawai'i at UTEP | Sat Nov 7, 12:00 AM | | | | |
| Northern Illinois at San José State | Sat Nov 7, 12:00 AM | | | | |
| Georgia State at App State | Sat Nov 7, 12:00 AM | | | | |
| Old Dominion at Coastal Carolina | Sat Nov 7, 12:00 AM | | | | |
| Marshall at Georgia Southern | Sat Nov 7, 12:00 AM | | | | |
| South Alabama at Louisiana | Sat Nov 7, 12:00 AM | | | | |
| Louisiana Tech at Troy | Sat Nov 7, 12:00 AM | | | | |
| North Carolina at UConn | Sat Nov 7, 12:00 PM | | | | |
| UL Monroe at Arkansas State | Sat Nov 7, 3:00 PM | | | | |
| Delaware at Kennesaw State | Sat Nov 7, 3:00 PM | | | | |
| Temple at Navy | Sat Nov 7, 3:30 PM | | | | |
| Western Kentucky at Middle Tennessee | Sat Nov 7, 3:30 PM | | | | |
| Missouri State at Florida International | Sat Nov 7, 4:00 PM | | | | |
| Liberty at New Mexico State | Sat Nov 7, 5:00 PM | | | | |
| Boise State at Colorado State | Sat Nov 7, 6:00 PM | | | | |
| Sam Houston at Jacksonville State | Sat Nov 7, 7:00 PM | | | | |
| No. 6 Miami at No. 3 Notre Dame | Sat Nov 7, 7:30 PM | Notre Dame -6.5 | 54.5 | | |
| Air Force at Army | Sat Nov 7, 7:30 PM | | | | |
| Fresno State at Utah State | Sat Nov 7, 9:30 PM | | | | |
| Texas State at Oregon State | Sat Nov 7, 10:30 PM | | | | |
| Wyoming at UNLV | Sat Nov 7, 10:30 PM | | | | |