Derrius Guice is a retired NFL running back who last played for the Washington Commanders. He was selected with pick 59 of round 2 in the 2018 NFL Draft out of LSU. In the 2019 regular season he caught 7 passes for 79 yards and 1 touchdown and rushed for 245 yards and 2 touchdowns on 42 carries. He finished as the PPR RB69 in 2019. At LSU (2015–17) he ran 471 times for 3,074 yards and 29 touchdowns and caught 32 passes for 250 yards and 3 touchdowns.