NFL 2025 - Week 12 MNF - David's Picks

By David · November 25, 2025

David's NFL Week 12 Monday Night Football Betting Picks & Predictions (with Units)

The GridironAI Betting Model has locked in its top value plays for Week 12 of the NFL season. Using advanced analytics, player performance trends, and line-movement data, these are David's best bets for this week.

David does the research and uses our models so you don't have to.

Week 12 MNF Picks

Pick Opponent Units
Carolina Panthers +7.5 vs Dallas Cowboys 5U
Pick Line Units
49ers / Panthers Under 49 Game Total 2U

Game Analysis

The Panthers are one of the biggest suprises this season. With a pre-season win total of 6.5, they are just one win away from that, with a record of 6-5. And one of those losses was with Andy Dalton as QB. Now they visit Santa Clara to take on the 49ers. The Panthers have the 6th worst passing offense in league. But they have been much more effective on the ground, with a top 10 ground game. The 49ers pass defense is allowing the 5th most yards per game, so this should play in the Panthers favor. Plus the 49ers defense hasn't been nearly as good since Nick Bosa and Fred Warner landed on the IR. When you exclude the first 3 games of the season when both of those guys played, the 49ers are giving up an average of 278 passing yards per game, which would rank dead last by a wide margin. Now, Bryce Young isn't exactly an elite QB, or even a good QB for that matter. But I don't need him to put up Matthew Stafford numbers against this defense. Just for him to be serviceable. The 49ers have a new kicker this week. Starting kicker Eddy Pineiro is hurt, and the 49ers signed Matt Gay, who was cut by the Commanders last week, as their kicker. Pineiro is 6-6 on FGs over 50 yards this season. Gay is 4-9. So that certainly is a step down in terms of reliability for long kicks. All these factors have me on the Panthers +7.5. The 49ers should win the game, but 7.5 points is just too much. The newly built GridironAI spread models went 12-1 this week, and 83% of these models like the Panthers to cover. The GridironAI team total models project 45 points to be score, which implies value on the Under 49.


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All odds current as of publication. Make sure you shop around at different sports books to get the best odds and line to maximize your return. Always wager responsibly.